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News: New Clues To ALS And Alzheimer's... (NPR News) - Behind the headlines

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NPR News July 8, 2020

New Clues To ALS And Alzheimer's Disease From Physics

by Jon Hamilton

Structures inside healthy brain cells nimbly move from one state to the next to perform different functions. But in certain degenerative brain diseases, scientists now think, that process gets stuck.

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Research findings and data from the National Library of Medicine

PubMed articles

Science MAY 21, 2009

Germline P granules are liquid droplets that localize by controlled dissolution/condensation

CP Brangwynne et al

In sexually reproducing organisms, embryos specify germ cells, which ultimately generate sperm and eggs. In Caenorhabditis elegans, the first germ cell is established whe …

Nat Rev Neurol JANUARY 1, 2019

Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease

NB Nedelsky et al

Biomolecular condensation arising through phase transitions has emerged as an essential organizational strategy that governs many aspects of cell biology. In particular, …

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WIRED JANUARY 10, 2021

A Newfound Source of Cellular Order in the Chemistry of Life

Inside cells, droplets called condensates merge, divide, and dissolve. Their dance may regulate vital processes.

The Guardian JANUARY 1, 2020

Protein tangles in Alzheimer's patients could help predict brain shrinkage

Research suggests tangles of tau could be used to predict how much shrinkage will occur and where

NPR News OCTOBER 21, 2019

Keeping Your Blood Sugar In Check Could Lower Your Alzheimer's Risk

Diabetes can double a person's chances of developing Alzheimer's. Now researchers are beginning to understand the role of brain metabolism in the development of the disease.

The New York Times JUNE 22, 2020

Living in Poverty May Increase Alzheimer’s Risk

People living in the poorest neighborhoods had the highest risk for brain changes typical of Alzheimer’s disease.

NIH Research Matters FEBRUARY 4, 2020

Predicting Alzheimer’s disease progression

A study suggested that PET imaging of tau tangles in the brain could be a way to track development of Alzheimer’s disease, predict loss of brain tissue, and assess new treatments.