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News: 2 Arthritis Drugs Reduce Deaths in... (The New York Times) - Behind the headlines

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The New York Times January 8, 2021

2 Arthritis Drugs Reduce Deaths in Very Ill Covid Patients, Study Finds

by Katherine J. Wu

The big dip in mortality shown in the trial of about 800 patients has caught some experts by surprise because previous studies of the drugs showed little benefit.

Read more at The New York Times

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PubMed articles

N Engl J Med JANUARY 7, 2021

Tocilizumab in Patients Hospitalized with Covid-19 Pneumonia

C Salama et al

In hospitalized patients with Covid-19 pneumonia who were not receiving mechanical ventilation, tocilizumab reduced the likelihood of progression to the composite outcome …

JAMA Intern Med JANUARY 1, 2021

Effect of Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With COVID-19 Pneumonia: A Randomized Clinical Trial

C Salvarani et al

In this randomized clinical trial of hospitalized adult patients with COVID-19 pneumonia and Pao2/Fio2 ratio between 200 and 300 mm Hg who received tocilizumab, no benefi …

JAMA Intern Med JANUARY 1, 2021

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial

O Hermine et al

In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS …

N Engl J Med DECEMBER 10, 2020

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19

JH Stone et al

Tocilizumab was not effective for preventing intubation or death in moderately ill hospitalized patients with Covid-19. Some benefit or harm cannot be ruled out, however, …

JAMA Intern Med JANUARY 1, 2021

Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19

S Gupta et al

Among critically ill patients with COVID-19 in this cohort study, the risk of in-hospital mortality in this study was lower in patients treated with tocilizumab in the fi …

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The New York Times NOVEMBER 8, 2020

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The Washington Post OCTOBER 20, 2020

New results from a once-promising therapy show the difficulty of treating covid-19

The drug, tocilizumab, showed early potential but evidence since then has been conflicting.

NPR News SEPTEMBER 2, 2020

Inexpensive Steroids Can Save Lives Of Seriously Ill COVID-19 Patients

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The Washington Post SEPTEMBER 2, 2020

Steroids can save lives of patients with severe covid-19, earning WHO endorsement

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NIH Research Matters DECEMBER 8, 2020

Hydroxychloroquine doesn’t benefit hospitalized COVID-19 patients

In a final analysis of study data, researchers concluded that the medication hydroxychloroquine provides no benefit to adults hospitalized with COVID-19.